The recognition of extracellular molecules by cell surface receptors is the principal mechanism used by cells to sense their environment. Consequently, signals transduced as a result of these interactions make a major contribution to the regulation of cellular phenotype. Historically, particular emphasis has been placed on elucidating the intracellular consequences of growth factor and cytokine binding to cells. In addition to these interactions, however, cells are usually in intimate contact with a further source of complex structural and functional information, namely (...) immobilised extracellular matrix and/or cell surface adhesion proteins. A key question in recent years has been whether cells use the myriad of adhesion protein‐receptor interactions purely for structural and migratory function, or whether these interactions also make a more varied contribution to cell phenotype. Here we review dynamic aspects of the function of one major class of adhesion receptor, the integrins. In particular, we focus on the evidence for shape changes in integrin molecules, the mechanisms responsible for regulating ligand binding, and the signals transduced following integrin occupancy. (shrink)

In this paper, I develop the concept ofaffective milieusby building on the recently established notion ofaffective arrangements. Affective arrangements bring together the more analytical research of situated affectivity with affect studies informed by cultural theory. As such, this concept takes a step past the usual synchronic understanding of situatedness toward an understanding of the social, dynamic, historical, and cultural situatedness of individuals in relation to situated affectivity. However, I argue that affective arrangements remain too narrow in their scope of analysis (...) since their focus mainly lies on local, marked-off, and unique constellations of affect relations. They neglect the more mundane and day-to-day affect dynamics of social life. Hence, I introduce the notion of affective milieus, which brings to light the everyday, ubiquitous affective engagements of individuals with their socio-material surroundings. Affective milieus specifically call attention to how commonplace affect relations create territories in the social universe which form and mold individuals all the time. In that way, this paper apprehends and advances recent developments in the research on situated affectivity. (shrink)

This is the first volume of an impressive project on the relation of art, philosophy and social change. In an on-going argument and review ing several important aesthetic theories Paul Crow ther in this book argues for the idea that aesthetics should be a kind of critical assessment of art w orks' experiential consequences. Although I go along w ith his resistance against postmodernist reasoning, w hich functions as the starting point of his book, beyond that, our w ays (...) often part. My disagreement, how ever, does not annul the evident quality of the argument in this w ork. It is recommended reading material for all those aestheticians w ho are interested in the cognitive and non-cognitive functionality of art w orks and in the possibility of any influence of art on societal change. I w ill now discuss the most crucial steps in Crow ther's argument. Postmodernists claim to have undone the alleged rigidity of modern categories, like that of the autonomous subject, but according to Crow ther they reach this `achievement' by overemphasizing the fluidity of modes of know ledge and experience, and of their status as social constructs, but there may w ell exist flexible constants. Aesthetics can help w ith the analysis of these flexible constants, not by looking for the essences of art or aesthetic experience, but by supplementing our theoretical assessments w ith a critique of art. Crow ther proposes to view aesthetic experiences as w ell as w orks of art as functions of critical aw areness and of body-hold, an historicized version of Merleau-Ponty's much neglected notion of embodiment. Critical aesthetics actualizes the critical aw areness involved in our aesthetic experiences. Art, defined in terms of originality, roots in the body-hold of the artist, w ho moulds his medium to solve technical problems traditional art forms confront him w ith. Postmodernism involves only tw o theses, really. First, contemporary experience and sensibility are analyzed as imbued by the shocks generated by the rapid succession of mechanically reproduced events.. (shrink)

ABSTRACTWhat did “historical distance” mean to historians in the Rankean tradition? Although historical distance is often equated with temporal distance, an analysis of Ernst Bernheim's Lehrbuch der historischen Methode reveals that for German historians around 1900 distance did not primarily refer to a passage of time that would enable scholars to study remote pasts from retrospective points of view. If Bernheim's manual presents historical distance as a prerequisite for historical interpretation, the metaphor rather conveys a need for self‐distanciation. Self‐distanciation is (...) not a Romantic desire to “extinguish” oneself, but a virtuous attempt to put one's own ideas and intuitions about the working of the world between brackets in the study of people who might have understood the world in different terms. Although Bernheim did not explicitly talk about virtue, the article shows that his Lehrbuch nonetheless considers self‐distanciation a matter of virtuous behavior, targeted at an aim that may not be fully realizable, but ought to be pursued with all possible vigor. For Bernheim, then, distance requires epistemological virtue, which in turn calls for intellectual character, or what Bernheim's generation considered scholarly selfhood . Not a mapping of time onto space, but a strenuous effort to mold “scholarly characters,” truly able to recognize the otherness of the past, appears to be characteristic of Bernheim's view of historical distance. (shrink)

This book invites you into conversation with some of the great minds who have formed history; those who have thought and dreamed great things, shaping and moulding the culture and the civilisation we have inherited. Silent Legacy is the story of philosophy: from ancient Greece to the contemporary West; a primer, an introduction to digging a little deeper. In this book we see the gradual rippling out of Kantian consequence; from Nietzsche's deconstruction of objective morality, to Kierkegaard's subjectivity, Wittgenstein's deconstruction (...) of self, Foucault's critique of power, and Derrida's deconstruction of language. The gradual loss of confidence in philosophy, and in the objective knowability and reality of the world, leaves us standing at the cross-roads once more. We observe how one thinker's words inspire or infuriate another, prompting them to more words and action. We ponder the cost of all this, considering the massive intellectual and social repercussions, for instance, of Rousseau's, Nietzsche's and Derrida's work. As ideas permeate down from the academic ivory tower to the street, the pub and the cafe, we can see them begin to affect wider culture and the way we live our lives. Platonic longing for the transcendent, Aristotelian scientific method, Nietzschean rejection of weakness, Rousseau's emphasis on freedom, Cartesian dualism or postmodern suspicion of authority - we can see them all in our contemporary world, still forming our legal, cultural, moral and popular culture. To grapple with these giants of philosophy, politics and thought, we must be brave and unafraid, but more than that, willing "to strive, to seek, to find" and, if yielding, doing so only to conviction and truth. (shrink)

This article examines the significance of the image of the Chimera which Socrates invites Glaucon to mould in Book IX of Republic. It argues that the image, when explicitly intended to represent the just and rationally autonomous individual soul, must also, in keeping with Socrates’ methodological procedure in the dialogue, correspond to a political structure. We argue that, as it cannot correspond to or represent the structure of the Kallipolis, the city this soul would correspond to would be the (...) approximately just polis from which the Kallipolis could emerge. The question thus arises as to what kind of individual or which class of persons each part of the tripartite soul can be assigned in a political context. We conclude that the answer supplied and best supported by the dialogue is a rule of the philosopher over a demos or tyrant through the intermediary aid of a rhetorician. (shrink)

I suggest that the core ideas of Kit Fine’s Semantic Relationism are the notion of semantic requirement and the notion of manifest consequence, the non-classical logical relation associated with semantic requirement. Surrounding this core are novel “relational” systems of coordinated sequences of expressions, relational (as opposed to intrinsic) semantic values, coordinated propositions, and coordinated content. I take Fine to take the periphery to be reducible to the core (but see below). I will make some primarily exegetical remarks about the two (...) core ideas, and then make more critical remarks about the periphery. I should say that I find the book, as a whole, illuminating and, for the most part, convincing. I hesitantly suggest that the core constitutes an important and novel model for thinking about semantics (and representation in general), while the periphery might result from an attempt to force the new model into the old mold. (shrink)

During the two last decades, speeded up by the development of the Internet, several types of commons have been opened up for intellectual resources. In this article their variety is being explored as to the kind of resources and the type of regulation involved. The open source software movement initiated the phenomenon, by creating a copyright-based commons of source code that can be labelled `dynamic': allowing both use and modification of resources. Additionally, such a commons may be either protected from (...) appropriation (by `copyleft' licensing), or unprotected. Around the year 2000, this approach was generalized by the Creative Commons initiative. In the process they added a `static' commons, in which only use of resources is allowed. This mould was applied to the sciences and the humanities in particular, and various Open Access initiatives unfolded. A final aspect of copyright-based commons is the distinction between active and passive commons: while the latter is only a site for obtaining resources, the former is also a site for production of new resources by communities of volunteers (`peer production'). Finally, several patent commons are discussed, which mainly aim at preventing patents blocking the further development of science. Throughout, attention is drawn to interrelationships between the various commons. (shrink)

Énoncée comme « impératif catégorique » de l'acte d'appropriation ordonné à l'avènement de l’« Homme total », la révolution prolétarienne dérive dans les écrits du jeune Marx d'un choix éthique s'alignant sur une ontologie de la vie moulée dans la pensée spéculative d'origine hégélienne.In the writings of young Karl Marx, the proletarian revolution is formulated as the "categorical imperative" of the appropriation act towards the coming of "totally unalienated Man"; and it derives from an ethical choice, based on an ontology (...) moulded in speculative thought from hegelian origin. (shrink)

The purpose of this paper is to theoretically explore in what ways Information and Communication Technology corresponds with knowledge sharing in organizations. We will address the research question: “What notions and relationships have been proposed in the literature regarding ICT use and knowledge sharing?” In order to draw connecting lines between different bodies of literature, we developed two notions of ICT performance as a guiding principle in reviewing the literature. On the one hand, ICT is portrayed as a guide that (...) moulds ways of knowledge sharing, and on the other hand ICT is described as a facilitator that follows existing knowledge sharing processes in organizations. The two types of ICT performance offer a tool with which approaches and perspectives on ICT in processes of knowledge sharing can be interconnected and displayed in one overview. This systematic research overview that connects separate notions and ideas coming from different disciplines results in a synthesis of research questions that are relevant for future research on the role of ICT in knowledge sharing in organizations. (shrink)

Israel Scheffler's ground-breaking essay, On Human Potential, deserves to be more widely known among educational policy analysts, especially in light of the popularity in educationist circles of W.E. Deming's organizational philosophy known as Total Quality Management . In what follows,I argue that the heuristical value of Deming's perscriptions are entailed in Scheffler's On Human Potential. More importantly, I argue, where Deming's work falls short, especially in being naive about the human condition, Scheffler's analysis provides a foundation for management theory in (...) education that insures the flourishing of an optimal number of contributing participants. In fashioning these ideas, Scheffler brings pioneering thinking to the emerging fields of management studies generally and educational policy specifically. (shrink)

Research on positive psychology demonstrates that specific individual dispositions are associated with more desirable outcomes. The relationship of positive psychological constructs, however, has not been applied to the areas of business ethics and social responsibility. Using four constructs in two independent studies (hope and gratitude in Study 1, spirituality and generativity in Study 2), the relationship of these constructs to sensitivity to corporate social performance (CSCSP) were assessed. Results indicate that all four constructs significantly predicted CSCSP, though only hope and (...) gratitude interacted to impact CSCSP. Discussion focuses upon these findings, limitations of the study, and future avenues for research. (shrink)

In 1894 the anthropologist Otis Tufton Mason called for research in an area he dubbed ‘technogeography’, and he lauded the potential benefits of the knowledge to be acquired under this heading: The...

At a historic dialogue convened at the University of Richmond, Virginia, Baptist and secular humanist scholars in theology, history, philosophy, and the social sciences, came together to define shared concerns and common values. The dialogue focused on major areas of concern: academic freedom; social, political, and religious tolerance; biblical scholarship; separation of church and state; the social agenda of the Christian Coalition and the Southern Baptist Convention; the danger of militant fundamentalism; freedom of conscience and the historic and current role (...) of American Baptists; as well as the plight of pluralistic democracy. (shrink)

The biblical image of Wisdom as the power who “orders all things well” in nature and in human life can be read in the light of contemporary information theory. Some current scientific speculation offers an interpretation of reality as a vast information‐processing system, in which informational situations are continuously transformed through algorithmic operations. This interpretation finds a metaphysical counterpart in the distinction between “nature natured” and “nature naturing” in the philosophical theology of Samuel Taylor Coleridge. This confluence of religious, metaphysical, (...) and scientific imagery suggests a picture of the world in which the processes of “nature naturing,”“human humaning,” and “God Godding” inform and recur in each other. (shrink)

The reputation of Rudolf Hermann Lotze was high in the philosophic world, especially the English-speaking philosophic world, during the period 1880–1920. One encyclopedia of the period says that “in the U. S. his influence is stronger in academic philosophy, perhaps, than that of any other author.” In typical histories of philosophy Lotze is counted among the great successors in the tradition of Kant and Hegel. I have elsewhere sought to explain the reasons for his great influence. Writers contemporary to Lotze (...) wanted first to classify him as an Herbartian, and in spite of his protests, he seemed some sort of Kantian or Hegelian. The character of his philosophy remained enigmatic, and he was sometimes called an “eclectic” since his philosophy contained aspects that reminded readers of some predecessor or other. But clearly he resisted the tendency to make all questions problems of knowledge: “The constant whetting of the knife is tedious, if it is not proposed to cut anything with it.” And clearly he is no Hegelian. He considered the rationalistic search for a single principle and a single method to have failed. German philosophy had failed to respect what is given in experience. Even in aesthetics, where surely one might be expected to attend to what the arts present for sensuous enjoyment, German intellectualism, to Lotze’s disgust, tended to use a deductive method. Santayana accused a priori German philosophers of “egotism”; he might have learned this from Lotze who found this same tradition marked by pretension. Only God could satisfy the program of Fichte. The demand of an all-embracing system is that it “make all particular parts of it pass before [us] in the majestic succession of an unbroken development!” Wrote Lotze, “It seemed to me that only a Spirit who stood in the centre of the universe which he himself had made could, with knowledge of the final aim which he had given his creation…” see the whole. Lotze’s kind of philosophy is professedly modest, nondogmatic, fallibilist. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)